Louisville shot a season-high 65 percent (30 of 46) from the floor and Montrezl Harrell added 18 points.
The Cardinals look to bounce back against Pittsburgh on Sunday, Jan. 25.
Chris Jones scored 22 points and Terry Rozier added 15 to lead Louisville
Chris Jones led the team with 22 points and 10 assists in win over the Demon Deacons.
Rozier led the way with 7-of-14 shooting, seven rebounds and three assists for the Cardinals.
USATSI photos men's basketball -- 1/25/15
Louisville Men's Basketball v Duke
USATSI photos men's basketball -- 1/17/15
Louisville Men's Basketball v Virginia Tech
Louisville vs. Virginia Tech (USATSI)