With Friday's win, the Cardinals improved to 23-7 at home this season and are 178-68 (.723 winning percentage) all-time at Jim Patterson Stadium since it opened in April 2005.
With their two runs on Friday, the Cardinals increased their scoring advantage in the first inning this season to 82-10 overall.
Louisville improved to 20-8 this season when scoring in the first inning and 28-8 when scoring first.
Friday marked the Cardinals' fourth shutout win of the season.
Friday's announced crowd of 3,058 was the Cardinals' second largest at home this season.
Louisville, which entered the week ranked second in the nation in hit-by-pitch, added three more to the total on Friday taking the season total to 99.
Junior Justin Amlung earned career win No. 23, which placed him in sole possession of second on the Cardinals' all-time list behind only Justin Marks' 29 from 2007-09.
With his six strikeouts on Friday, Amlung moved into sixth on the Cardinals' career list with 226 and into a tie for seventh on the single season list with Zack Pitts (2007) at 91.
The four hits on Friday for sophomore Ty Young were a career-high. After Friday's action, he leads the Cardinals in hitting at .364.
With his two RBI on Friday, senior Stewart Ijames moved into a third-place tie on the Cardinals' career list at 201 with Richie Hawks (1988-91). Ijames leads the Cardinals this season with 54 RBI.
Sophomore outfielder Adam Engel returned to the Cardinals' starting lineup on Friday for the first time since he suffered an injured thump on his left (non-throwing) hand against Seton Hall on April 15. Overall, he missed 12 games and was out of the lineup for 13 games.
After Friday's action, Louisville (15-7) sits alone in second in the BIG EAST standings, one game behind first-place St. John's (16-6). USF and Connecticut are tied for third at 14-8, while Seton Hall is fifth at 13-9 with five BIG EAST games left in the regular season race.