With their sixth straight win against the Hoyas, the Cardinals hold a 14-3 advantage in the all-time series with Georgetown.
The Cardinals improved to 22-0 this season when leading after the seventh inning.
Louisville is 18-2 this season when scoring first.
The Cardinals improved to 11-1 this season against left-handed starting pitchers.
A day after hitting five Louisville batters, Georgetown pitchers had four more HBPs on Friday.
In the last 11 games, Louisville's bullpen has allowed just one earned run in 31.2 innings pitched for a microscopic 0.28 ERA. They also have 40 strikeouts in that stretch.
Louisville has outscored its opponents 30-14 in the second inning this season, including a 4-0 advantage on Friday. In the first two innings this season, the Cardinals have an 84-21 scoring edge.
With his team-leading 10th home run of the season on Friday, senior Stewart Ijames moved into a tie for eighth on the Cardinals' career home run list with Richie Hawks (1988-91) with 43 home runs.
With his two RBI on Friday, Ijames has 184 in his career, which places him tied for eighth on the Cardinals' career list with Rob Newman (1989-92).
With two hits each on Friday, both junior Nick Ratajczak and sophomore Ty Young have 11 multiple-hit performances this season, which is tied for the team lead with sophomore Adam Engel.
With his two RBI on Friday, freshman Zach Lucas has seven multiple-RBI games this season, which ranks second on the team behind Ijames' 12.
With their 7-1 conference record, the Cardinals remain atop the BIG EAST standings in a first-place tie with USF and Connecticut.