With their fifth straight win against the Hoyas, the Cardinals hold a 13-3 advantage in the all-time series with Georgetown.
The Cardinals improved to 22-0 this season when leading after the seventh inning.
Louisville is 17-2 this season when scoring first.
Cardinal batters were hit five times by Hoya pitchers on Thursday setting a new season high for Louisville.
In the last 10 games, Louisville's bullpen has allowed just one earned run in 29.2 innings pitched for a microscopic 0.30 ERA. They also have 36 strikeouts in that stretch.
Junior Justin Amlung won his fifth straight start and has pitched at least 7.0 innings in each of last seven starts.
With the win on Thursday, Amlung earned his 21st career victory, which places him tied for third on Louisville's career win list with Mike Shields (1975-78).
In his last four starts, Amlung has allowed only three earned runs with 35 strikeouts in 28.2 innings pitched for an ERA of just 0.94.
The seven saves for Self in 2012 place him tied for 10th on the Cardinals' single season save list with Kerry Griffith (1984).
With his two RBI on Thursday, freshman Zach Lucas has seven multiple RBI performances this season, the second most for Louisville.
With their 6-1 conference record, the Cardinals remain atop the BIG EAST standings in a first-place tie with USF and Connecticut.
