With Tuesday's win, the Cardinals even the all-time series with the Hoosiers at 19-19. Louisville has won 10 of the last 12 in the series.
The Cardinals are 7-2 at home this season and 162-63 (.720) all-time at Jim Patterson Stadium.
The 13 runs and 15 hits were both season highs for the Cardinals.
The 13 runs were the most since the 14-2 win over Notre Dame on May 19, 2011.
The 15 hits were the most since they finished with 15 in an 11-2 win over Kent State on March 22, 2011.
Louisville has played error-free baseball in four straight games marking the longest stretch of games without an error for the Cardinals since they went four straight during the 2010 NCAA Regional (June 4-7).
All nine starters in the Louisville lineup on Tuesday had a hit.
The five runs in the first inning on Tuesday matched a season-high for runs in a single inning equaling the five scored in the fourth inning of the 7-4 win over Oakland.
With his two hits on Tuesday, senior Stewart Ijames has hit safely in nine straight games, the Cardinals' longest streak of the season.
In the Cards' nine-game homestand which ended on Tuesday, Ijames hit .375 with four home runs, 11 RBI, five walks and a .844 slugging percentage.
With his 2-for-4 performance on Tuesday, sophomore Adam Engel earned his team-leading seventh multi-hit game of the season.
Through 12 games this season, Louisville has stolen 24 bases in 29 attempts while limiting opponents to only 10 in 15 attempts.
Ijames leads the Cardinals with 11 RBI, while Gardner is next with 10.
Louisville is 7-0 this season when scoring first.
The Cardinals are 9-0 when leading after the sixth inning.
Through the first 12 games, Louisville has a .322 team batting average while opposing batters are hitting just .223 against Cardinal pitching.
Freshman righty Joe Ceja pitched a scoreless inning of relief in the eighth to become the 11th different first-year Cardinal to see game action in 2012.
